rapid and sensitive lc-msms method for the determination of metoprolol in beagle dog plasma with a simple protein precipitation treatment and its pharmacokinetic applications快速和敏感lc-msms方法测定美托洛尔治疗与一个简单的小猎犬狗血浆蛋白沉淀及其药代动力学的应用程序.pdfVIP

Molecules 2012, 17, 2663-2674; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Rapid and Sensitive LC-MS/MS Method for the Determination of Metoprolol in Beagle Dog Plasma with a Simple Protein Precipitation Treatment and Its Pharmacokinetic Applications 1 1 2 1 3 1 1 Sha Li , Xingli Wang , Kelong Peng , Zhiguo Ma , Xiaoqi Zhang , Shaolian Fu , Xiaofei Li , Linlin Li 1, Aihua Hong 4 and Jie Jiang 5,* 1 Department of Pharmaceutics, Jinan University College of Pharmacy, Guangzhou 510632, China; E-Mails: tlisha@ (S.L.); roddick18@126.com (X.W.); mzg1979@126.com (Z.M.); liankefsl@163.com (S.F.); xiaofei.li2009@163.com (X.L.); daisy.lee920@163.com (L.L.) 2 College of Pharmacy, Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China; E-Mail: sunpkl@163.com 3 Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University College of Pharmacy, Guangzhou 510632, China; E-Mail: xqzhang7401@ 4 Jinan University Analytical and Testing Center, Guangzhou 510632, China; E-Mail: hah_angel@126.com 5 Institute of New Drug Research, Jinan University College of Pharmacy, Guangzhou 510632, China * Author to whom correspondence should be addressed; E-Mail: jiejiang2008@; Tel.: +86-20-8522-0461; Fax: +86-20-8522-4766. Received: 31 January 2012; in revised form: 22 February 2012 / Accepted: 27 February 2012 / Published: 5 March 2012 Abstract: A rapid L