resonant photonic biosensors with polarization-based multiparametric discrimination in each channel谐振光子生物传感器与polarization-based multiparametric歧视在每个通道.pdfVIP

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resonant photonic biosensors with polarization-based multiparametric discrimination in each channel谐振光子生物传感器与polarization-based multiparametric歧视在每个通道.pdf

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resonant photonic biosensors with polarization-based multiparametric discrimination in each channel谐振光子生物传感器与polarization-based multiparametric歧视在每个通道

Sensors 2011, 11, 1476-1488; doi:10.3390/s110201476 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Article Resonant Photonic Biosensors with Polarization-Based Multiparametric Discrimination in Each Channel Robert Magnusson 1,2,*, Debra Wawro 2, Shelby Zimmerman 2 and Yiwu Ding 2 1 Department of Electrical Engineering, University of Texas at Arlington, Box 19016, Arlington, TX 76019, USA 2 Resonant Sensors Incorporated, 416 Yates Street, 518 NH, Arlington, TX 76010, USA; E-Mails: wawro@ (D.W.); zimmerman@ (S.Z.); dingyw99@ (Y.D.) * Author to whom correspondence should be addressed; E-Mail: magnusson@; Tel.: +1-817-272-2672; Fax: +1-817-272-2253. Received: 10 December 2010; in revised form: 4 January 2011 / Accepted: 18 January 2011 / Published: 26 January 2011 Abstract: In this paper, we describe guided-mode resonance biochemical sensor technology. We briefly discuss sensor fabrication and show measured binding dynamics for example biomaterials in use in our laboratories. We then turn our attention to a particularly powerful attribute of this technology not possessed by competing methods. This attribute is the facile generation of multiple resonance peaks at an identical physical location on the sensor surface. These peaks respond uniquely to the biomolecular event, thereby enriching the data set available for event quantification. The peaks result from individual, polarization-dependent