study on the immunomodulation effect of isodon japonicus extract via splenocyte function and nk anti-tumor activityisodon对虾的免疫调节作用研究提取通过脾细胞功能和nk抗肿瘤活性.pdfVIP
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study on the immunomodulation effect of isodon japonicus extract via splenocyte function and nk anti-tumor activityisodon对虾的免疫调节作用研究提取通过脾细胞功能和nk抗肿瘤活性
Int. J. Mol. Sci. 2012, 13, 4880-4888; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Study on the Immunomodulation Effect of Isodon japonic us
Extract via Splenocyte Function and NK Anti-Tumor Activity
Yu-Jin Hwang 1,2, Jaehyun Kim 1, Dong-Sik Park 1 and Kyung-A Hwang 1,*
1 Department of Agrofood Resources, National Academy of Agricultural Science, RDA,
Suwon 441-853, Korea; E-Mails: yujinh21@ (Y.-J.H.);
kjh2002@korea.kr (J.K.); dpark@korea.kr (D.-S.P.)
2 Department of Biotechnology Bioengineering, Sungkyunkwan University,
Suwon 440-746, Korea
* Author to whom correspondence should be addressed; E-Mail: kah366@korea.kr;
Tel.: +82-31-299-0527; Fax: +82-31-299-0443.
Received: 4 January 2012; in revised form: 6 March 2012 / Accepted: 5 April 2012 /
Published: 18 April 2012
Abstract: Here we investigated the potential immune-enhancing activity of
Isodon japonicus on murine splenocyte and natural-killer (NK) cells in vitro. The ethanol
extract of I. japonicus significantly enhanced the proliferation of splenocyte and induced
the significant enhancement of NK cells’ activity against tumor cells (YAC-1). In addition,
I. japonic us increased the production of interferon (IFN)-γ and tumor necrosis factor
(TNF)-α, suggesting that the increase in NK cell cytotoxicity could be due to the
enhancement of the NK c
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