subjective memory complaints, vascular risk factors and psychological distress in the middle-aged a cross-sectional study主观记忆投诉、血管危险因素和心理压力在中年的横断面研究.pdfVIP

Paradise et al. BMC Psychiatry 2011, 11:108 /1471-244X/11/108 RESEARCH ARTICLE Open Access Subjective memory complaints, vascular risk factors and psychological distress in the middle-aged: a cross-sectional study 1* 1 1 2 1 Matt B Paradise , Nick S Glozier , Sharon L Naismith , Tracey A Davenport and Ian B Hickie Abstract Background: Subjective memory complaints (SMC) are common but their significance is still unclear. It has been suggested they are a precursor of mild cognitive impairment (MCI) or dementia and an early indicator of cognitive decline. Vascular risk factors have an important role in the development of dementia and possibly MCI. We therefore aimed to test the hypothesis that vascular risk factors were associated with SMC, independent of psychological distress, in a middle-aged community-dwelling population. Methods: A cross-sectional analysis of baseline data from the 45 and Up Study was performed. This is a cohort study of people living in New South Wales (Australia), and we explored the sample of 45, 532 participants aged between 45 and 64 years. SMC were defined as ‘fair’ or ‘poor’ on a self-reported five-point Likert scale of memory function. Vascular risk factors of obesity, diabetes, hypertension, hypercholesterolemia and smoking were identified by self-report. Psychological distress was measured by the Kessler Psychological Distress Scale. We tested the model generated from a randomly selected exploratory sample (n = 22, 766) with a confirmatory sample of equal size. Results: 5, 479/45, 532 (12%) of respondents reported SMC. Using multivariate logistic regression, only two vascular risk factors: smoking (OR 1.18; 95% CI = 1.03 - 1.35) and hypercholesterolaemia (OR 1.19