surface modification of poly(l-lactic acid) nanofiber with oligo(d-lactic acid) bioactive-peptide conjugates for peripheral nerve regeneration表面改性的聚(l-lactic酸)纳米纤维低聚糖(d-lactic酸)bioactive-peptide配合周围神经再生.pdfVIP

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surface modification of poly(l-lactic acid) nanofiber with oligo(d-lactic acid) bioactive-peptide conjugates for peripheral nerve regeneration表面改性的聚(l-lactic酸)纳米纤维低聚糖(d-lactic酸)bioactive-peptide配合周围神经再生.pdf

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surface modification of poly(l-lactic acid) nanofiber with oligo(d-lactic acid) bioactive-peptide conjugates for peripheral nerve regeneration表面改性的聚(l-lactic酸)纳米纤维低聚糖(d-lactic酸)bioactive-peptide配合周围神经再生

Polymers 2011, 3, 820-832; doi:10.3390/polym3020820 OPEN ACCESS polymers ISSN 2073-4360 /journal/polymers Article Surface Modification of Poly(L-lactic acid) Nanofiber with Oligo(D-lactic acid) Bioactive-Peptide Conjugates for Peripheral Nerve Regeneration Sachiro Kakinoki 1,2, Sho Uchida 1,3, Tomo Ehashi 1,2, Akira Murakami 3 and Tetsuji Yamaoka 1,2,* 1 Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan; E-Mails: sachiro@ri.ncvc.go.jp (S.K.); shou_uchida@gg.nitto.co.jp (S.U.); @tmd.ac.jp (T.E.) 2 JST, CREST, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan 3 Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan; E-Mail: akiram@kit.ac.jp (A.M.) * Author to whom correspondence should be addressed; E-Mail: yamtet@ri.ncvc.go.jp; Tel.: +81-6-6833-5012 ext. 2637; Fax: +81-6-6835-5476. Received: 22 February 2011 / Accepted: 27 April 2011 / Published: 27 April 2011 Abstract: In some traumatic nerve injuries, autologous nerve grafting is the first choice for bridging the gap between the severed nerve ends. However, this therapeutic strategy has some disadvantages, including permanent loss of donor function and requirement of multiple surgeries. An attractive alternative to this therapeutic technique is the use of artificial nerve conduit. Poly (L-lactic acid) (PLLA) is widely used as a substrate for artificial nerve condui