synthesis and antitumor evaluation of 6-aryl-substituted benzo[j]phenanthridine- and benzo[g]pyrimido[4,5-c]isoquinolinequinones合成和抗肿瘤的评价6-aryl-substituted苯并[j]菲啶和苯并[g]pyrimido isoquinolinequinones(4、5度).pdfVIP

下载本文档

0
0
约4.79万字
约 14页
2017-09-12 发布于上海
举报
版权申诉

synthesis and antitumor evaluation of 6-aryl-substituted benzo[j]phenanthridine- and benzo[g]pyrimido[4,5-c]isoquinolinequinones合成和抗肿瘤的评价6-aryl-substituted苯并[j]菲啶和苯并[g]pyrimido isoquinolinequinones(4、5度).pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

synthesis and antitumor evaluation of 6-aryl-substituted benzo[j]phenanthridine- and benzo[g]pyrimido[4,5-c]isoquinolinequinones合成和抗肿瘤的评价6-aryl-substituted苯并[j]菲啶和苯并[g]pyrimido isoquinolinequinones(4、5度)

Molecules 2012, 17, 11616-11629; doi:10.3390/molecules171011616 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Antitumor Evaluation of 6-Aryl-substituted benzo[j ]phenanthridine- and Benzo[g ]pyrimido[4,5-c]isoquinolinequinones Jennyfer Iribarra 1, David Vásquez 2,3, Cristina Theoduloz 4, Julio Benites 1,3, David Ríos 1,3 and Jaime A. Valderrama 3,5,* 1 Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile 2 Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380492, Chile 3 Instituto de EtnoFarmacología (IDE), Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile 4 Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Chile 5 Facultad de Química, Pontificia Universidad Católica de Chile, Casilla 306, Santiago 6094411, Chile * Author to whom correspondence should be addressed; E-Mail: jvalderr@uc.cl; Tel.: +56-02-354-4432; Fax: +56-02-354-4744. Received: 10 September 2012; in revised form: 23 September 2012 / Accepted: 25 September 2012 / Published: 28 September 2012 Abstract: A variety of novel 6-arylsubstituted benzo[j ]phenanthridine- and benzo[g]- pyrimido[4,5-c]isoquinolinequinones were synthesized from 1,4-naphthoquinone, aryl- aldehydes and enaminones via a two-step synthetic approach. The cytotoxic activity of the aminoquinone derivatives was evaluated in vitro against one normal cell line (MRC-5 lung fibroblasts) and three human cancer cell lines (AGS human gastric adenocarcinoma