the aryl hydrocarbon receptor-mediated disruption of vitellogenin synthesis in the fish liver cross-talk between ahr- and erα-signalling pathways卵黄蛋白原合成的芳基碳氢化合物受体介导中断之间的鱼肝相声ahr,erα-signalling通路.pdfVIP

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the aryl hydrocarbon receptor-mediated disruption of vitellogenin synthesis in the fish liver cross-talk between ahr- and erα-signalling pathways卵黄蛋白原合成的芳基碳氢化合物受体介导中断之间的鱼肝相声ahr,erα-signalling通路.pdf

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the aryl hydrocarbon receptor-mediated disruption of vitellogenin synthesis in the fish liver cross-talk between ahr- and erα-signalling pathways卵黄蛋白原合成的芳基碳氢化合物受体介导中断之间的鱼肝相声ahr,erα-signalling通路

Comparative Hepatology BioMed Central Research Open Access The aryl hydrocarbon receptor-mediated disruption of vitellogenin synthesis in the fish liver: Cross-talk between AHR- and ERα-signalling pathways 1,2 1 1,2 Vahid Bemanian , Rune Male* and Anders Goksøyr Address: 1Department of Molecular Biology, University of Bergen, POBox 7800, N-5020 Bergen, Norway and 2Biosense Laboratories AS N-5008, Bergen, Norway Email: Vahid Bemanian - Vahid.Bemanian@mbi.uib.no; Rune Male* - Rune.Male@mbi.uib.no; Anders Goksøyr - anders@ * Corresponding author Published: 02 May 2004 Received: 05 September 2003 Accepted: 02 May 2004 Comparative Hepatology 2004, 3:2 This article is available from: /content/3/1/2 © 2004 Bemanian et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: In the fish liver, the synthesis of egg yolk protein precursor vitellogenin (VTG) is under control of the estrogen receptor alpha (ERα). Environmental contaminants such as 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) are suspected to have antiestrogenic effects. The aryl hydrocarbon receptor (AHR) is the initial cellular target for TCDD and related compounds. The AHR is a ligand-activated transcription factor that stimulates the expression of the genes encoding xenobiotic metabolizing enzymes, such as cytochrom