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the bioavailability of salbutamol in urine via volumatic and nonvolumatic valved holding chambers舒喘灵的生物利用度,尿液通过volumatic和nonvolumatic装有阀的房间
ORIGINAL ARTICLE
The Bioavailability of Salbutamol in Urine via Volumatic and
Nonvolumatic Valved Holding Chambers
Fanak Fahimi,1,2 Farzad Kobarfard,3 Jamshid Salamzadeh,1 Atefeh Fakharian,4 Pegah Abdolahi,1
Azita Hajhossein Talasaz,5 Hamid Mahboobi Pour,6 Shadi Baniasadi,7 and Mohammadreza Masjedi8
Conclusions: Although the results indicate that relative bioavail-
Purpose: Pressurized metered dose inhalers are commonly used in
ability to the lung after inhalation with Asthm Yar was significantly
patients with asthma. However, the need to coordinate inhalation
higher than after inhalation with Dam Yar, its clinical importance
with inhaler actuation means that they are not suitable for use per se. should be tested.
Valved holding chamber devices were developed to overcome some
of the problems of pressurized metered dose inhalers. Several types Key Words: asthma, valved holding chamber, urinary concentration,
of holding chambers of different sizes are available in Iran. This salbutamol, spirometry
study was designed to compare the effects of 2 commonly used
(WAO Journal 2011; 4:179– 183)
valved holding chambers (Asthm Yar and Dam Yar) in Iran on
bioavailability of salbutamol spray and also spirometric parameters
in asthmatic patients. he majority of asthmatic patients continue to use pressurized
Methods: This was a comparative experimental crossover study. Taerosol
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