原创力文档the cardiac ventricular 5-ht4 receptor is functional in late foetal development and is reactivated in heart failure心脏心室5-ht4受体功能在胎儿后期开发和激活在心力衰竭.pdfVIP
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the cardiac ventricular 5-ht4 receptor is functional in late foetal development and is reactivated in heart failure心脏心室5-ht4受体功能在胎儿后期开发和激活在心力衰竭
The Cardiac Ventricular 5-HT4 Receptor Is Functional in
Late Foetal Development and Is Reactivated in Heart
Failure
1,2,3 1,2,6 1,2,6 1,2 1
Trond Brattelid , Eirik Qvigstad , Lise R. Moltzau , Silje V. S. Bekkevold , Dagny L. Sandnes ,
Jon Arne K. Birkeland2,4, Tor Skomedal1,2,6, Jan-Bjørn Osnes 1,2,6, Ivar Sjaastad2,4,5,6, Finn Olav Levy1,2,6*
1 Department of Pharmacology, Faculty of Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway, 2 Center for Heart Failure Research, Faculty of
Medicine, University of Oslo, Oslo, Norway, 3 National Institute of Nutrition and Seafood Research, Bergen, Norway, 4 Institute for Experimental Medical Research,
University of Oslo and Oslo University Hospital, Oslo, Norway, 5 Department of Cardiology, Oslo University Hospital - Ullevaal, Oslo, Norway, 6 K. G. Jebsen Cardiac
Research Centre, Oslo, Norway
Abstract
A positive inotropic responsiveness to serotonin, mediated by 5-HT4 and 5-HT2A receptors, appears in the ventricle of rats
with post-infarction congestive heart failure (HF) and pressure overload-induced hypertrophy. A hallmark of HF is a
transition towards a foetal genotype which correlates with loss of cardiac functions. Thus, we wanted to investigate whether
the foetal and neonatal cardiac ventricle displays serotonin responsiveness. Wistar rat hearts were collected day 3 and 1
before expected birth (days -3 and -1), as well as day 1, 3, 5 and 113 (age matched with Sham and HF) after birth. Hearts
from post-infarction HF and sham-operated animals (Sham) were also collected. Heart tissue
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