combinatorial computational approaches to identify tetracycline derivatives as flavivirus inhibitors组合计算方法来确定四环素衍生物为黄病毒抑制剂.pdfVIP

Combinatorial Computational Approaches to Identify Tetracycline Derivatives as Flavivirus Inhibitors 1,2 1 1 1 1 Jinn-Moon Yang , Yan-Fu Chen , Yu-Yin Tu , Kuei-Rong Yen , Yun-Liang Yang * 1 Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, 2 Institute of Bioinformatics, National Chiao Tung University, Hsinchu, Taiwan Limited structural information of drug targets, cellular toxicity possessed by lead compounds, and large amounts of potential leads