contrasting epidemic histories reveal pathogen-mediated balancing selection on class ii mhc diversity in a wild songbird对比鲜明的流行历史揭示pathogen-mediated平衡选择在野生songbird二类mhc的多样性.pdfVIP

Contrasting Epidemic Histories Reveal Pathogen- Mediated Balancing Selection on Class II MHC Diversity in a Wild Songbird ¤ Dana M. Hawley* , Robert C. Fleischer Center for Conservation and Evolutionary Genetics, Smithsonian Institution, Washington D.C., United States of America Abstract The extent to which pathogens maintain the extraordinary polymorphism at vertebrate Major Histocompatibility Complex (MHC) genes via balancing selection has intrigued evolutionary biologists for over half a century, but direct tests remain challenging.