determining frequent patterns of copy number alterations in cancer确定的频繁模式拷贝数改变癌症.pdfVIP

Determining Frequent Patterns of Copy Number Alterations in Cancer Franck Rapaport, Christina Leslie* Computational Biology Program, Sloan-Kettering Institute, New York, New York, United States of America Abstract Cancer progression is often driven by an accumulation of genetic changes but also accompanied by increasing genomic instability. These processes lead to a complicated landscape of copy number alterations (CNAs) within individual tumors and great diversity across tumor samples. High resolution array-based comparative genomic hybridization (aCGH) is being us