differential regulation of cutaneous oncoprotein hpve6 by wtp53, mutant p53r248w and δnp63α is hpv type dependent微分调节皮肤肿瘤蛋白hpve6 wtp53,突变p53r248w和δnp63α是依赖人乳头状瘤病毒类型.pdfVIP

Differential Regulation of Cutaneous Oncoprotein HPVE6 by wtp53, Mutant p53R248W and DNp63a is HPV Type Dependent Jian-Wei Fei, Ethel-Michele de Villiers* Division for the Characterization of Tumorviruses, Deutsche Krebsforschungszentrum, Heidelberg, Germany Abstract UV exposure and p53 mutations are major factors in non-melanoma skin cancer, whereas a role for HPV infections has not been defined. Previous data demonstrated the wtp53-mediated degradation of cutaneous HPV20E6 by caspase-3. DNp63a and hot-spot mutant p53R248W conveyed a protective effect on