原创力文档differentiation generates paracrine cell pairs that maintain basaloid mouse mammary tumors proof of concept分化生成旁分泌细胞对维持碱性小鼠乳腺肿瘤的概念.pdfVIP
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differentiation generates paracrine cell pairs that maintain basaloid mouse mammary tumors proof of concept分化生成旁分泌细胞对维持碱性小鼠乳腺肿瘤的概念
Differentiation Generates Paracrine Cell Pairs That
Maintain Basaloid Mouse Mammary Tumors: Proof of
Concept
Soyoung Kim, Shruti Goel, Caroline M. Alexander*
McArdle Laboratory for Cancer Research, University of Wisconsin–Madison, Madison, Wisconsin
Abstract
There is a paradox offered up by the cancer stem cell hypothesis. How are the mixed populations that are characteristic of
heterogeneous solid tumors maintained at constant proportion, given their high, and different, mitotic indices? In this
study, we evaluate a well-characterized mouse model of
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