direct assessment of the effect of the gly380arg achondroplasia mutation on fgfr3 dimerization using quantitative imaging fret直接评估的影响gly380arg软骨发育不全突变在fgfr3二聚作用使用定量成像烦恼.pdfVIP

Direct Assessment of the Effect of the Gly380Arg Achondroplasia Mutation on FGFR3 Dimerization Using Quantitative Imaging FRET Jesse Placone, Kalina Hristova* Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America Abstract The Gly380Arg mutation in FGFR3 is the genetic cause for achondroplasia (ACH), the most common form of human dwarfism. The mutation has been proposed to increase FGFR3 dimerization, but the dimerization propensities of wild-type and mutant FGFR3 have not been compa