direct regulation of clock expression by rev-erb直接调节时钟由rev-erb表达式.pdfVIP

Direct Regulation of CLOCK Expression by REV-ERB Christine Crumbley, Thomas P. Burris* The Scripps Research Institute, Jupiter, Florida, United States of America Abstract Circadian rhythms are regulated at the cellular level by transcriptional feedback loops leading to oscillations in expression of key proteins including CLOCK, BMAL1, PERIOD (PER), and CRYPTOCHROME (CRY). The CLOCK and BMAL1 proteins are members of the bHLH class of transcription factors and form a heterodimer that regulates the expression of the PER and CRY genes. The nuclear r