effects of nk-4 in a transgenic mouse model of alzheimers diseasenk-4转基因小鼠模型的影响阿尔茨海默氏症.pdfVIP

Effects of NK-4 in a Transgenic Mouse Model of Alzheimer’s Disease Hitomi Ohta*, Shigeyuki Arai, Kenji Akita, Tsunetaka Ohta, Shigeharu Fukuda Research Center, Hayashibara Biochemical Laboratories, Inc., Okayama, Japan Abstract Beta-amyloid (Ab) peptides are considered to play a major role in the pathogenesis of Alzheimer’s disease (AD) and molecules that can prevent pathways of Ab toxicity may be potential therapeutic agents for treatment of AD. We have previously reported that NK-4, a cyanine photosensitizing dye, displays neurotrophic a