eif4a inhibition allows translational regulation of mrnas encoding proteins involved in alzheimers diseaseeif4a抑制允许平移监管信使rna编码的蛋白质参与阿尔茨海默氏症.pdfVIP

eIF4A Inhibition Allows Translational Regulation of mRNAs Encoding Proteins Involved in Alzheimer’s Disease Andrew Bottley, Nicola M. Phillips, Thomas E. Webb, Anne E. Willis, Keith A. Spriggs* School of Pharmacy, University of Nottingham, Nottingham, United Kingdom Abstract Alzheimer’s disease (AD) is the main cause of dementia in our increasingly aging population. The debilitating cognitive and behavioral symptoms characteristic of AD make it an extremely distressing illness for patients and carers. Although drugs have been developed to treat AD symptoms and to s