encephalomyocarditis virus viroporin 2b activates nlrp3 inflammasome脑心肌炎病毒viroporin 2 b激活nlrp3 inflammasome.pdfVIP

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome Minako Ito, Yusuke Yanagi, Takeshi Ichinohe* Department of Virology, Faculty of Medicine, Kyushu University, Maidashi, Higashi-ku, Fukuoka, Japan Abstract Nod-like receptors (NLRs) comprise a large family of intracellular pattern- recognition receptors. Members of the NLR family assemble into large multiprotein complexes, termed the inflammasomes. The NLR family, pyrin domain-containing 3 (NLRP3) is triggered by a diverse set of molecules and signals, and forms the NLRP3 inflammasome.