腹泻型肠易激综合征及幽门螺杆菌感染相关性探究.docVIP

腹泻型肠易激综合征及幽门螺杆菌感染相关性探究 　 作者：于大海，李奎栋，高乃复 【关键词】 幽门螺杆菌 　　［关键词］ 肠易激综合征；幽门螺杆菌；相关性　　 　　［摘 要］ 目的：评价腹泻型肠易激综合征（IBS）与幽门螺杆菌（HP）感染之间的关系。方法：将86例腹泻型IBS患者与92例健康体检者对照，用14C-尿素呼气试验法及快速尿素酶法检测HP感染情况，并根据检测结果将46例HP阳性的腹泻型IBS患者随机分为观察组和对照组。两组同时给予匹维溴胺、思密达治疗4周，观察组同时加用抗HP治疗2周，观察其总有效率。结果：腹泻型IBS组Hp感染率为53.5%，健康体检组HP感染率为51.1%，两组比较差异无显著性（P＞0.05）。HP阳性的腹泻型IBS患者疗效比较，观察组与对照组总有效率分别为87.5%和81.8%，差异无显著性（P＞0.05）。结论：腹泻型IBS与HP感染之间无明显相关性。 　　Study about the Correlation of Irritable Bowel Syndrome and Helicobacter Pylori 　　Abstract: Objective To study the influence of the helicobacter pylori infection on irritable bowel syndrome．Methods14Ｃurea respiratory test and fast urease examination were used to evaluate the infection of helicobacter pylori between 86 cases of irritable bowel syndrome and 92 healthy cases of control．The 46 cases of irritable bowel syndrome with helicobacter pylori were divided into observe group and control group by random．Pinaverium bromide and smecta were used to treat the all 46 cases．At the same time, antihelicobacter pylori therapy was used to observe group．Results The infection rate of irritable bowel syndrome is 53.5%．And that of healthy cases is 51.1%．There is no obvious difference between the two groups (Pgt;0.05)．Among the cases of irritable bowel syndrome with helicobacter pylori，the therapy effective rate of observe group is 87.5%，which has no obvious difference with the control group(81.8%)(Pgt;0.05)．Conclusion There is no obvious correlation between irritable bowel syndrome and helicobacter pylori． 　　Key words: Irritable bowel syndrome; Helicobacter pylori； Correlation 肠易激综合征（Irritable Bowel Syndrome，IBS）是一种以腹痛或腹部不适，伴排便习惯、性状改变为特征的功能性肠病。该病缺乏可解释症状的形态学改变和生化异常。IBS的病因及发病机制尚不完全清楚，一般认为与精神、饮食、胃肠动力障碍、肠道菌群失调及肠敏感性增强等因素有关［1］。幽门螺杆菌（Helicobacter Pylori，HP）是一种可以定植在胃黏膜中，并可对胃黏膜造成损害的革兰阴性螺旋形致病菌［2］。它是否是IBS的发病原因之一，目前尚无明确结论。该试验对这一问题进行初步探讨。 　　1 资料与方法 　　1．1 病例资料 　　腹泻型IBS组：选择自2002年6月至2004年12月来我院就诊的腹泻型IBS患者86例，其中男39例，女47例，平均年龄（45.6±11.3）岁。入选标准：年龄＞18岁，性别不限；症状符合IBS罗马Ⅱ标准［3］；经血、尿、便常规；血生化（血糖、肝，肾功能检查）；纤维胃十