启东肝癌防控策略的研究及现场干预的效果-tumor-肿瘤.pdfVIP

1052 　　肿瘤2014 年11 月第34 卷第11 期　TUM OR Vol. 34, November 2014 DOI: 10.3781/j .issn.1000-7431.2014.19.596 Copyright© 2014 by TUM OR Cancer Prevention and Treatment 肿瘤防治 · 启东肝癌防控策略的研究及现场干预的效果 陈建国，陈陶阳，朱源荣，朱　健，陆建华，王金兵，孙　燕，张永辉，吴　燕，陈永胜，陆玲玲 启东肝癌防治研究所，江苏启东　226200 [摘要]　启东肝癌防治现场在实践中确立了肝癌防控策略，并针对主要病因采取了综合性的干预措施，使肝癌标 化发病率下降44.35% ，标化死亡率下降44.20% ，特别是青年人肝癌发病率 （死亡率）的下降，在流行病学、生 态学和生物标志物方面均获得了可信的证据。启东肝癌防控的长期实践表明，针对危险因素开展综合防治和干预， 完全有可能取得一级预防和二级预防效果。 [关键词]　肝肿瘤；病因学；现场干预；流行病学；预防与控制；策略；启东 [中图分类号]　R730.1 [文献标志码] A [文章编号]　1000-7431 (2014) 11-1052-06 Research on strategies for prevention and control of liver cancer and the efficacy of field interventions in Qidong CHEN Jian-guo, CHEN Tao-yang, ZHU Yuan-rong, ZHU Jian, LU Jian-hua, WANG Jin-bing, SUN Yan, ZHANG Yong-hui, WU Yan, CHEN Yong-sheng, LU Ling-ling Qidong Liver Cancer Institute, Qidong 226200, Jiangsu Province, China [A BSTRACT]　This paper reports the strategies for prevention and control of liver cancer formed in the practice in Qidong field for liver cancer research, and the comprehensive measures aiming at the major risk factors in the past decades. The efficacy of these interventions is reflected in the substantial decrease in the rates of incidence and mortality of liver cancer in Qidong: the age-standardized rate of incidence rate is decreased by 44.35%, and the age-standardized rate of mortality is decreased by 44.20%, especially in younger population. These data are evidenced from the points of views in epidemiology, ecology, and biomarkers monitoring. The long-run profitability in the first prevention and secondary prevention can be benifited from the comprehensive control and intervention strategies in Qidong. [KEY WORDS]　Liver neoplasms; Etiology; Field intervention; Ep