肿瘤光动力学疗法与免疫效应分子（Photodynamic therapy and immune effector molecules）.doc

肿瘤光动力学疗法与免疫效应分子（Photodynamic therapy and immune effector molecules） Photodynamic therapy and immune effector molecules This article source: paper / Abstract photodynamic therapy (photodynamic, therapy, PDT) is an effective method for the treatment of tumors, and many immune effector molecules play an important role in PDT mediated local and systemic reactions. This review describes the changes in the expression of major immune effector molecules after tumor PDT and the progress in the study of tumor PDT synergism. Keywords photodynamic therapy; immune effector molecules; Neoplasms; Photodynamic therapy (photodynamic therapy, PDT) for its minimally invasive, selective effect and repeated implementation has attracted more attention in the treatment of malignant tumors and some benign diseases, its anti-tumor mechanisms including Dan Xiantai photosensitive effect oxygen directly kill tumor cells or inducing apoptosis, and tumor microvascular injury between the anti tumor immune reaction of matter, secondary 1. This review summarizes the role of the major immune effector molecules in tumor PDT, and the synergistic effects of PDT and its activators or inhibitors. 1 tumor PDT induced immune effector molecules change and function 1.1 cytokines 1.1.1 interleukin (interleukin, IL) Studies have shown that tumor PDT can induce multiple changes in IL expression and mediate inflammation and immune response in the host after treatment. De Vree 2 rats were found with rhabdomyosarcoma of phytochrome, as photosensitizer PDT, tumor growth delay, 2 h serum IL-1 increased significantly after treatment with 4 ~ 24 h, the number of mature blood neutrophils was significantly increased; the application of granulocyte colony stimulating factor (granulocyte colony-stimulating, factor, G-CSF) neutrophil antibody, only partially reduced PDT induced increased, but tumor growth delay time was shortened; that of IL-1 beta directly caused by bone marrow neutrophils release storage pool, and by ind