阿莫西林克拉维酸钾干混悬剂（Amoxicillin and clavulanate Potassium for Suspension）.docVIP

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2017-09-21 发布于河南
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阿莫西林克拉维酸钾干混悬剂（Amoxicillin and clavulanate Potassium for Suspension）.doc

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阿莫西林克拉维酸钾干混悬剂（Amoxicillin and clavulanate Potassium for Suspension）

阿莫西林克拉维酸钾干混悬剂（Amoxicillin and clavulanate Potassium for Suspension） Amoxicillin and clavulanate potassium Amoxicillin and for Clavulanate Potassium Suspension suspension (Austria first) This product is a compound preparation, its components are amoxicillin and clavulanate potassium, the ratio of 2 to 1 or 4: 1. [traits] This product is added flavoring powder; fragrance, sweet. [pharmacology and toxicology] This product is a compound preparation of amoxicillin and clavulanate potassium. Amoxicillin is broad-spectrum penicillin, potassium clavulanate itself only weak antibacterial activity, but inhibitory effect of strong broad-spectrum B lactam enzyme combination, can protect against amoxicillin B lactam enzyme hydrolysis. The antibacterial spectrum of this product is the same as amoxicillin, and it has expanded. Have a good effect on the enzyme production of Staphylococcus aureus, Staphylococcus aureus, coagulase negative Staphylococcus and Enterococcus, for some B producing enzyme in intestinal bacteria, bacteria liver, Haemophilus influenzae, Moraxella Mora bacteria, Bacteroides fragilis has better antibacterial activity. This product has no effect on Enterobacteriaceae and Pseudomonas such as methicillin resistant Staphylococcus and enterobacter. [pharmacokinetics] This product is good for gastric acid stability, oral absorption, food absorption of this product has no significant impact. Fasting oral 375mg (amoxicillin, 250mg, and clavulanic acid, 125mg) and amoxicillin reached the peak concentration (Cmax) at 1.5 hours, which was about 5.6mg/L. The blood elimination half-life (t1/2b) is about 1 hours. The excretion rate of 8 hours urine was 50% ~ 78%. The pharmacokinetic parameters of clavulanic acid were the same as those for single use, and the peak blood concentration (Cmax) of 1 hours after oral administration of clavulanic acid (125g) was about 3.4mg/L in normal subjects. Protein binding rate ranged from 22% to 30%. The blood elimination half-life (t1/2b) r