精神活性物质检测技术的研究进展.pdfVIP

刑事技术 2015 年 第40 卷 第4 期 ·综  述· DOI: 10.16467/j.1008-3650.2015.04.013 精神活性物质检测技术的研究进展 李 彭，贺剑锋，刘克林，张春水，高利生，郑 珲 * （公安部物证鉴定中心 北京市现场物证检验工程技术研究中心，北京 100038） Psychoactive Substances Analysis: A Literature Review * LI Peng, HE Jianfeng, LIU Kelin, ZHANG Chunshui, GAO Lisheng, ZHENG Hui (Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Ministry of Public Security, Beijing , China) 100038 ABSTRACT: In the past decades, an ever-increasing number of new psychoactive substances (NPSs) have appeared in the recreational drug market, and analytical toxicologists have to continuously adapt new screening methods to identify the latest NPSs. The daunting challenges are how to accurately monitor the state of NPSs and how to determine an enormous range of trace and ultra-trace analytes present in sample matrixes with complex or variable compositions. Here we present a critical overview of the analysis of some of the most commonly encountered and most dangerous substances. The rational method development, validation and transfer of robust gas chromatography-mass spectrometry (GC-MS), and important factors impacting the incurred sample analysis are discussed. The mature technologies coupled with GC-MS used in most quantitative bioanalytical laboratories, such as hollow fiber-based liquid phase microextraction (HF-LPME), electrosorption- enhanced solid-phase microextraction (EE-SPME), are also covered. Liquid phase separation techniques coupled with mass spectrometry (LC-MS), is also expounded in this paper. Due to its high specificity, speed and selectivity, LC-MS has long been deploye