TCF7L2基因rs7903146和rs11196218单核苷酸多态性与新诊断2型糖尿病患者早相胰岛素分泌的相关性分析.PDFVIP

　 2011 3 1 36 3 Med J Chin PLA, Vol.36, No.3, March 1, 2011　 ·269 · TCF7L2 基因rs7903146 和r单核苷酸多态性 与新诊断2 型糖尿病患者早相胰岛素分泌的相关性分析 郑晓雅,任伟,张素华,刘静婧,李素芳,李金超,许丹,毕健琨 [] 　　7 2(TCF7L2)rs7903146 rSNPs) 2 (T2DM)。　-, T2DM (n=227)(n =152), (MALDI-TOF MS) rs7903146 rNPs。　 T2DM rs7903146 (MAF)5.73%4.28%, 。Logistic 、、, rs7903146 rNPsT2DM (P0.05)。Rs7903146 SNPs ΔI /ΔG (OR=1.012, 95%CI 1.000～ 1.025,P=0.05),T ΔI /ΔG 30 30 30 30 (P=0.0385)。　TCF7L2 rs7903146 rSNPs T2DM , rs7903146 。 　　[]　, 2 ;7 2;, 　　[]　R587.1　　　　　[]　A 　　　　　[]　0577-7402(2011)03-0269-04 Correlation between single nucleotide polymorp isms of rs7903146 and rat TCF7L2 gene and t e early p ase insulin secretion of newly diagnosed patients wit type 2 diabetes ＊ HENG Xiao-ya, REN Wei , HANG Su-hua, LIU Jing-jing, LI Su-fang, LI Jin-chao, XU Dan, BI Jian-kun. Department of Endocrinology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China ＊Corresponding author, E-mail:weiren67 @ [Abstract] 　Objective　To investigate the correlation between single nucleotide polymorphisms (SNPs)of rs7903146 and r at TCF7L2 gene and the early phase insulin secretion of new ly diagnosed patientswith type 2 diabetes mellitus (T2DM).Met ods　A case- control study was conducted in 227 newly diagnosed patients with T2DM (T2DM group)and 152 normal people (control group)from Chongqing area.SNPs of rs7903146 and rwere genotyped by matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS).Results　The minor allele frequencies (MAF)of rs7903146 in T2DM and control group were 5.73% and 4.28%, respectively, with no significant difference.Logistic regression analysis revealed that the SNPs of rs7903146 and r were n