冠心病患者合并代谢综合征危险因素与冠脉病变相关性研究.docVIP

冠心病患者合并代谢综合征危险因素与冠脉病变相关性研究 张少敏1，夏志琦1，朱 蕾1，彭晓玲1，黄德生2 （1深圳市孙逸仙心血管医院内科，深圳518021；2中国医科大学数理统计教研室，沈阳110001） 摘要： 目的 探讨冠心病（Congenital heart diseaseCHD）合并代谢综合征（metabolic syndromeMS）患者与冠状动脉病变（coronary atherosclerotic heart diseaseCAD）严重程度的相关关系。 方法 入选经冠动脉造影确诊冠心病429例。按冠心病是否合并代谢综合征进行分组。所有患者均查体重指数（BMI）、血压（BP）、空腹血糖（FBG）、甘油三脂（TG）、高密度脂蛋白（HDLc）、总胆固醇（TC）、低密度脂蛋白（LDLc）、血尿酸（UA）及年龄、性别、吸烟等。 结果 合并代谢综合征组的BMI、BP、FBG、TG、HDLc、TC、LDLc、UA均显著高于与单纯冠心病组P0.05），冠脉病变Gensini 评分和病变支数明显增加P0.01）； HDLc、LDL-cBMI与冠脉病变程度相关显著P0.01）。 结论 冠心病患者合并代谢综合征可加重冠脉病变严重程度，HDLc、LDLc、BMI可作为预测冠状动脉狭窄严重程度的参考指标之一。 关键词: 冠心病；代谢综合征；冠动脉疾病；危险因素 Study of the relationship between risk factors of coronary heart disease with metabolic syndrome and coronary artery disease ZHANG Shaomin，Xia zhiqi，Zhu lei et，al. Department of Cardiology，Shenzhen cardiology hospital 518021 AbstractObjective To investigate the relationship between risk factors of coronary heart disease with metabolic syndrome and coronary artery disease . Methods 429 cases were finally diagnosed to have coronary heart disease by coronary arteriongraphy. The cases were divided into CHD group with MS and CHD group. All cases tested BMI、BP、FBG、TG、HDL-cTC、LDL-c、age、、smoking et al. Results the CHD group with MS were higher than that in the CHD group (P 0.01 or P 0.05). The Gensini score and number of vessal disease significantly increased(P 0.01). The severity of the coronary artery disease in CHD group with MS was significantly correlated with HDLc、LDL-c and BMI (P0.01). Conclusion Coronary heart disease with MS aggravate the severity of coronary artery disease. HDLc、LDLc、BMI play a important role in prediction of serious coronary artery disease. Key words: coronary heart disease; metabolic syndrome; coronary artery disease; risk facter 随经济的发展，集肥胖、血脂紊乱、高血压、和高尿酸血症等多种心血管病危险因素于一身的代谢综合征的发病呈明显上升趋势，在大中城市，已成为公共严重。metabolic syndrome，MS)是一种包含多个代谢方面相关危险因子共同作用的疾病，常伴随肥胖和致动脉粥样硬化的血脂障碍、高血压、葡萄糖耐量降低、血栓形成前状态和促炎症反应阶段[1]。在冠心病（coronary heart desease，CHD）患者中，冠心病合并代谢综合征的死亡率显著增加[2、3]。近年来有关冠