线粒体电压依赖性阴离子通道与心血管疾病-中国动脉硬化杂志.pdfVIP

CN43鄄1262/ R摇 中国动脉硬化杂志2013年第21卷第6期 567 [文章编号]摇 1007鄄3949(2013)21鄄06鄄0567鄄06 ·文献综述 · 线粒体电压依赖性阴离子通道与心血管疾病 夏 晶摇 综述,李元建,江俊麟摇 审校 (中南大学药学院药理学系,湖南省长沙市410078) [关键词]摇 电压依赖性阴离子通道;摇 心血管疾病;摇 氧化应激;摇 细胞凋亡 [摘摇 要]摇 电压依赖性阴离子通道(VDAC)是位于线粒体外膜的通道蛋白,是线粒体与细胞质之间转运ATP 以及 其他代谢产物的主要通道,在线粒体代谢和细胞生长中发挥重要调控作用。 近期研究发现,在心肌缺血再灌、糖尿 病、心衰、高血压和动脉粥样硬化时,VDAC表达明显增加,引起细胞内钙离子循环紊乱、氧化应激,进而导致细胞 凋亡,已成为心血管疾病研究的新热点。 本文就VDAC的分子功能,调控及其在心血管疾病中的作用和相关机制 进行综述。 [中图分类号]摇 R363 [文献标识码]摇 A Voltage鄄dependent Anion Channel and Cardiovascular Diseases XIA Jing,LI Yuan鄄Jian,andJIANGJun鄄Lin (Department of Pharmacology,College of Pharmacy,Central South University,Changsha,Hunan410078,China) [KEY WORDS]摇 Voltage鄄Dependent Anion Channel;摇 Cardiovascular Diseases;摇 Oxidative Stress;摇 Cell Apoptosis [ABSTRACT]摇 The voltage鄄dependent anion channel (VDAC),a mitochondrial membrane channel protein located in the outer of mitochondrial membrane,is the main pathway between mitochondria and cytoplasm exchanging ADP,ATP, and other metabolites,and plays an important role in mitochondrial metabolism and cell growth.摇 A growing evidence showed that VDACwasincreasedincardiovasculardiseasesincludingmyocardialischemiaandreperfusion,diabetes,heart failure,hypertension and atherosclerosis.摇 The abnormal state of VDACwill result in cell death by inducing calcium cyc鄄 ling dysfunction and oxidative stress.摇 AndVDAChasbecome ahot topic inthefieldof cardiovascular diseasesresearch. 摇 In this article,wewill introduce the molecular function and regulation of VDAC and its role in cardiovascular diseases. 摇 摇 电压依赖性阴离子通道(voltage dependent anion 平行 茁鄄链的折叠和25个氨基酸残基形成琢鄄螺旋结