软骨细胞退化.PPTVIP

Bone 1. Characteristics: bone tissue + medullary cavity bone marrow + periosteum endosteum bone tissue= cells + bone matrix (fibers + calcified g.s.) hard rigid support, protection for calcium storage Organic (35%); inorganic (65%) Organic part: collagenous fibers (90%) + amorphous g.s. Inorganic part (bone mineral): mainly hydroxyapatite crystal responsible to hardness 3. Cells A.?Osteogenitor cell Location: inner layer of periosteum endosteum L.M.: Small, spindle shape, weak basophilic Function: Stem cell, differentiate into osteoblast B. Osteoblast Location: at surface of bone tissue in a layer; LM: Pear-shaped, strong basophilic, large pale nucleus EM: short processes; rich in rER Gl. osteoblast fibers g.s osteoid embedded osteoblasts C. Osteocyte Location: embedded in calcified matrix LM: Flat ovoid cell body (in lacunae) long fine processes (in canaliculi), acidophilic. tissue fluid fills in lacunae canaliculi EM: gap junction b/w connected processes Function: for intercellular communication D. Osteoclast Location: In depression on the bone surface LM: Giant cell Irregular multinucleate (2-50, fusion of monocytes) acidophilic striated border(Sb) EM: Mv.(ruffled border) ring clear zone Lysosomes Phagocytosis vacuoles Others: Mit. rER. Function: Clear zone: attached the bone surface to form a microenvironment Mv.: increase the absorptive area absorb the dissolved products * belong to the mononuclear phagocyte system 4. Bone architecture long bone diaphyses (compact bone) epiphyses (sponge bone) Spongy bone Location: Structure: