WNK1与原发性高血压相关性研究进展WNK1与原发性高血压相关性研究进展.pdfVIP

Advances in Clinical Medicine 临床医学进展, 2014, 4, 47-52 Published Online September 2014 in Hans. /journal/acm /10.12677/acm.2014.43009 The Progress in the Study of the Correlation between the WNK1 Gene and Primary Hypertension 1 2* Li Wang , Saihua Yu 1 The Affiliated Hospital Of Inner Mongolia Medical University, Hohhot 2 Inner Mongolia Medical University, Hohhot * Email: 779334266@ th st th Received: Aug. 11 , 2014; revised: Sep. 1 , 2014; accepted: Sep. 11 , 2014 Copyright © 2014 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Abstract WNK1 was the first member found in WNK family; it has multiple transcription start sites and dif- ferent transcription products in different tissues. Further researches found that the deletion of Intein-1 in WNK1 gene can lead to Gordon syndrome. WNK1 is a regulatory protein of the renal iron transporters and channels, and plays a very important role in maintaining renal potassium, sodium and chlorine ions balance as well as the regulation of blood pressure, so the WNK1 gene is considered a key genes for essential hypertension. In addition, the WNK1 gene polymorphism may be linked to the susceptibility of the essential hypertension in general population. This review shows the source, structure and function of the WNK1, and investigates the correlation between primary hypertension and WNK1 aimed at guiding anti-hypertensive drugs clinical drug regi- ments and forecasts. Keywords Essential Hypertension, Wnk1 Gene, Go