102例ⅲa（n2）期非小细胞肺癌的远期疗效分析.docVIP

精品论文 参考文献 102例ⅢA（N2）期非小细胞肺癌的远期疗效分析 黄雪洁1 罗泽民2 1广东医学院 广东湛江 524000；2广东省农垦中心医院肿瘤科 广东湛江 524000 【摘 要】目的 比较ⅢA（N2）期非小细胞肺癌患者手术和非手术治疗的远期疗效。方法 收集2007年1月-2010年8月在我院治疗的ⅢA（N2）期非小细胞肺癌患者的临床资料，并对这些患者的生存情况进行随访，采用Kaplan-Meier法计算生存率和绘制生存曲线，比较手术治疗组和非手术治疗组的生存差异。结果 全组患者中位生存期为25.6个月，1、3和5年生存率分别为83.3%、34.4%和20.6%。手术治疗组的中位生存期26.5个月，1、3和5年生存率分别为87.1%、33.9%和21.0%，中位无进展生存期为13.3个月；非手术治疗组的中位生存期23.0个月，1年、3年和5年生存率分别为77.5%、35.0%和20.0%，中位无进展生存期12.5个月，两组整体生存和中位无进展生存期差异均无统计学意义（P＞0.05）。结论 手术治疗可能未能提高ⅢA（N2）期NSCLC的总生存率和延长无进展生存期。 【关键词】非小细胞肺癌；N2期；治疗；远期疗效 Analysis of long-term effect in 102 patients with ⅢA（N2）non-small cell lung cancer Huang Xue-jie1，Luo Ze-min2 1Guangdong Medical College，Guangdong Zhanjiang 524000；2Department of Medical Oncology，Guangdong Nongken Central Hospital，Guangdong Zhan jiang 524000 Abstract：Objective This study aims to compare the difference in long-term effect between surgical therapy and non-surgical therapy in stage ⅢA（N2）non-small cell lung cancer（NSCLC）.Methods The clinical data of stage ⅢA（N2）NSCLC who was treated from Jan.2007 to Aug.2010 were collected.We followed up survival status of these patients.Kaplan-Meier method was used to calculate the survival rate and plot the survival curve to compare the survival difference between the two groups.Results In the whole group，median survival time was 25.6 months，and 1-，3- and 5-year survival rates were 83.3%，34.4% and 20.6%.The median survival time，1-，3-，5-year and the median time progression free survival（PFS）survival rates were 26.5 months，87.1%，33.9%，21.0% and 13.3 months in operation group，and 23.0 months，77.5%，35.0%，20.0% and 12.5 months in non-operation group.The difference wasnrsquo;t statistically significant in overall survival and PFS of the two groups（P＞0.05）.Conclusion Surgery may not improve overall survival and prolong PFS of stage ⅢA（N2）NSCLC. Key words：Non-small cell lung cancer；Stage N2；Therapy；Long-term effect Ⅲ期非小细胞肺癌（non-small cell lung cancer，NSCLC）约占所有NSCLC30%，主要为ⅢA（N2）[1]。根据SEER（Surve