363例重症监护病房患者感染病原菌分布及耐药性分析.docVIP

精品论文 参考文献 363例重症监护病房患者感染病原菌分布及耐药性分析 梁玉兰 张晓凯 赵新惠 潘士虎 田新村 　　（山东省滨州市中心医院检验科 山东 惠民 251700） 　　【摘要】 目的：了解重症监护病房(ICU)患者感染病原菌分布特点及耐药情况,为控制医院感染及临床选用抗菌药物治疗提供依据。方法：分析2011年12月-2014年12月ICU患者送检的各类标本中分离出的病原菌，进行病原菌耐药性分析。结果:分离出病原菌363株，标本来源中痰液阳性标本居首位，占77.4%；病原菌仍以革兰阴性杆菌为主,占69.7%，革兰阳性球菌占6.9%，真菌占总构成比23.4%。肺炎克雷白杆菌和大肠埃希菌产超广谱beta;-内酰胺酶(ESBLs)检出率分别61.2%和75%，耐甲氧西林葡萄球菌(MRSA)检出率为48.5%。结论:ICU为医院感染高发科室，病原菌仍以革兰阴性杆菌为主,坚持细菌耐药性监测,?对ICU患者感染的诊治具有重要指导意义。? 　　【关键词】??重症监护病房;医院感染;病原菌;耐药性 　　【中图分类号】R446 【文献标识码】A 【文章编号】2095-1752（2015）13-0062-02 　　 Distribution of pathogens and drug resistance analysis in 363 case of ICU patients 　　Liang Lulan，Zhang Xiaokai, Zhao Xinhui , Pan Shihu Tian Xincun.Central Hosptal of Binzhou 251700,China 　　【Abstract】?Objective??To?investigate?pathogen?distribution?and?antimicrobial?resistance?in?the?intensive?care?unit?(ICU)?for?the?control?of?hospital?infection?and?guidance?of?antibiotic?clinical?use?of?drug?therapy.?Methods??From?December?2011-?December?2014. ICU patients for all kinds of specimens in isolated pathogens, pathogenic bacteria drug resistance analysis.?Results??363?pathogens?were?isolated.Sputum-positive?samples?ranked??the?first?and?accounted?for?77.4%;?pathogenic?Gram-negative?bacilli?were?still?dominated,?accounted?for?69.7%?andGram-positive?cocci?accounted?for?6.9%,??fungi?accounted?for?23.4%?of?the?total?composition; Pneumonia Cray white Campylobacter and Escherichia coli?ultra-extended-spectrum?beta;-lactamases?(ESBLs)?had?a?detection?rate?of61.2%and75%?,?methicillin-resistant?Staphylococcus?aureus?(MRSA)?had?a??detection?rate?of?48.5?%.?Conclusion??The?rate?of?hospital?infection?was?high?in?ICU.?The?pathogens?were?mainly?Gram-negative?bacteria.?Bacterial?resistance?surveillance?in??ICU?patients?would?be?helpful?for??hospital-acquired?infection?diagnosis?and?treatment. 　　【Key?words】Intensive?care?unit;?Nosocomial?infection;?Pathogenic?bacteria;?Drug?resistance 　　随着抗菌药物的广泛应用，多重耐药菌已成为医院感染的重要病原菌，这种现象在ICU病房尤为突出。ICU患者