446例尘肺病病人下呼吸道感染的病原菌分布及耐药情况分析.docVIP

精品论文 参考文献 446例尘肺病病人下呼吸道感染的病原菌分布及耐药情况分析 湖南武冈展辉医院 422400 【摘 要】目的：分析446例尘肺病病人下呼吸道感染的病原菌分布及耐药情况。方法：病例资料来源于我院2013年4月至2015年4月收治的尘肺病病人下呼吸道感染患者446例，培养口痰进行细菌鉴定，分析耐药情况。结果：446例尘肺病人中检出110例病原菌株，其中真菌7株，占6.4%，包括白色念珠菌和其他真菌。革兰氏阳性菌13株，占11.8%，包括金黄色葡萄球菌，表皮葡萄球菌和其他革兰氏阳性菌。革兰氏阴性菌90株，占81.9%，革兰氏阴性菌中的铜绿假单胞菌对氨苄西林、阿莫西林、头孢西丁、头孢他啶等耐药性较高，而肺炎克雷伯菌及大肠埃希菌对氨苄西林、头孢西丁、环丙沙星、左氧氟沙星等耐药性较高。结论：尘肺病患者下呼吸道感染主要分布的病原菌为革兰氏阴性菌，应该加强细菌耐药情况检测，有针对性的选择药物方案，减少出现耐药菌株，改善临床抗菌药物的合理应用。 【关键词】尘肺病；下呼吸道感染；病原菌；耐药情况 [Abstract]objective：to analyze 446 cases of pneumoconiosis patients with lower respiratory infection of pathogenic bacteria distribution and drug resistance.Methods：the clinical data from our hospital between April 2013 and April 2015 were 446 cases of patients with lower respiratory tract infection in patients with pneumoconiosis，cultivate mouth bacteria identification of phlegm，analysis of drug resistance.Results：446 cases of pneumoconiosis patients detected in 110 cases of pathogenic bacteria strains，7 strains of fungi，accounted for 6.4%，including candida albicans and other fungi.Gram positive bacteria strains，accounting for 11.8%，including staphylococcus aureus，epidermis staphylococcus aureus and other gram-positive bacteria.90 strains of gram-negative bacteria，accounting for 81.9%，gram negative bacteria pseudomonas aeruginosa in to ampicillin，amoxicillin，cefoxitin，cephalosporins he organism such as high resistance，and klebsiella pneumoniae and e.coli to ampicillin，cefoxitin，ciprofloxacin，levofloxacin and high resistance.Conclusion：pneumoconiosis patients with lower respiratory infection main distribution of pathogenic bacteria are gram-negative bacteria，should strengthen detecting drug-resistant bacteria，the choice of targeted drugs，reduce the resistant strain，improve clinical reasonable application of antimicrobial agents. [Key words]pneumoconiosis；The lower respiratory tract infection；Pathogenic bacteria；Drug resistance situation 尘肺病是一种全身性疾病，大多是因职业活动期间，吸入大量粉尘于肺内潴留从而导