3 Anticancer Drugs抗肿瘤药物.pptVIP

Anti-Cancer Drugs Cancer center, Sun Yat-sen University Quentin Liu Overview Introduction Overall 5-year survival : about 40%, Mortality: second. Overview Tumor susceptibility and cell cycle undifferentiated and rapidly dividing cells a. cell cycle specificity b. tumor growth rate Overview Cell-cycle specificity of drugs: Overview Antimetabolites Folic acid Antagonists: MTX Purine Antagonists: 6-MP 6-TG Pyrimidine Antagonists: 5-FU ara-C HU Antimetabolites Methotrexate (MT