分化型甲状腺癌（DTC）术后131I治疗最佳出院时间的研究.docVIP

精品论文 参考文献 分化型甲状腺癌（DTC）术后131I治疗最佳出院时间的研究 倪发强 　　（浙江省肿瘤医院核医学科 浙江 杭州 310022） 　　【摘要】 目的：探讨分化型甲状腺癌（DTC）患者术后131I治疗住院时间的相关问题。方法：以58例甲状腺切除术后行131I治疗的甲状腺乳头状癌患者为研究对象，分为低剂量治疗组27例( 治疗剂量为3700MBq) 和高剂量治疗组31例(治疗剂量7400MBq) 分别测量患者服药后48h、72h 1m 距离处的放射性辐射剂量，同时以400MBq的131I作为参考放射源。结果：低剂量治疗组和高剂量治疗组服药后48h放射性辐射剂量差异有统计学意义(t=2.311,P=0.028)所有患者服药后72h的放射性辐射剂量均低于参考源，17例患者(低剂量治疗组5例，高剂量治疗组12例)服药后48h的放射性辐射剂量高于参考源。结论：分化型甲状腺癌（DTC）患者行131I治疗后72h的放射性辐射剂量迅速下降，且明显低于国家规定???400Mb的辐射剂量，可出院后自行隔离。大剂量131I治疗的患者，服药后48h的放射性辐射剂量较高。 　　【中图分类号】R736.1 【文献标识码】A 【文章编号】2095-1752（2016）18-0062-02 　　Study on the suitable hospitalization length of differentiated thyroid cancer patients administrated with 131I Ni Faqiang. Department of Nuclear Medicine, Zhejiang Cancer Hospital,Zhejiang Province, Hangzhou 310022,China 　　【Abstract】Objective To research the property hospitalization length of differentiated thyroid cancer(DTC) patients who administrated with 131I.MethodsA total of 58 cases of DTC patients who accepted bilateral thyroidectomy as researchedsubjects. To divided patientsby the administrated 131I dose as low-dose group(n=27, Dose=3700MBq) and high-dose group(n=31, Dose=7400MBq).The radioactive dose of all patients at 48h and 72h after 131I administration were measured at a distance of 1m, and 400MBq 131Ias control source.ResultsThere were statistically significant (t=2.311, p=0.028) of low and high-dose group patients after administrated with 131I at 48h. The radioactive doses of low and high-dose group patients were lower than control source after 72h 131I administration. The radioactive doses of 17 cases patients (low-dose group 5 cases, high-dose group 12 cases)were higher than control source (n=27, Dose=3700MBq).Conclusion The radioactive dose of DTC patients who accepted131I administration decreased obviously after 72h and lower than national criterion of 400 Mb obviously. Those patients could discharge from hospital and perform self-isolation. However, the high-dose group