中药淫羊藿对绝经后骨质疏松的临床治疗研究.docxVIP

中药淫羊藿对绝经后骨质疏松的临床治疗研究【摘要】目的探究中药淫羊藿对绝经后骨质疏松的临床效果。方法选取2014年10月至2015年12月来我院就诊的60例绝经后骨质疏松症患者为研究对象，随机分为对照组和观察组。对照组给予阿仑膦酸钠片，观察组在此基础上给予口服淫羊藿总黄酮胶囊，两组患者均治疗24周。记录并统计两组患者的血钙，血磷和血镁的含量，骨形成指标（ALP、BALP、BGP）和骨吸收指标（β-CTX、TRACP-5b、BMD）的变化。并记录两组患者的临床总有效率及不良反应发生情况。结果两组患者的血钙水平均升高，血磷和血镁的水平均下降（P0.05）。观察组患者在治疗后ALP、BALP、BGP、β-CTX、TRACP-5b、BMD等指标明显高于治疗前，具有统计学意义（P0.05）。对照组患者的指标变化不显著（P0.05）。对照组的总有效率达到73.33%，观察组临床总有效率为93.33%，差异显著具有统计学意义（P0.05）。两组患者均出现不良反应，对照组10例，观察组1例。结论中药淫羊藿可以增加绝经后的骨质疏松症患者的骨密度、降低骨形成及骨吸收的指标水平，具有良好的效果。【关键词】淫羊藿；阿仑膦酸钠片；绝经后骨质疏松症；Clinical study on the treatment of postmenopausal osteoporosis with traditional Chinese MedicineEpimedium[Abstract] Objective To explore the clinical effect of traditional Chinese medicine Epimediumon postmenopausal osteoporosis.MethodsFrom October 2014 to December 2015, 60 postmenopausal osteoporosis patients in our hospital were randomly divided into two groups: control group and observation group. The control group was given Alendronate Sodium Tablets, the observation group was given oral administration of the Epimedium capsule, two groups of patients were treated for 24 weeks. Records and statistics of two groups of patients with serum calcium, serum phosphorus and magnesium content of blood, bone formation index (ALP, BALP, BGP) and bone absorption index (P -CTX, TRACP-5b, BMD) index changes. The clinical total effective rate and adverse reaction of the two groups were recorded. ResultsThe results of the two groups of patients with serum calcium levels were increased, serum phosphorus and serum magnesium levels were decreased (P0.05). In the observation group after treatment, BALP, BGP, ALP, beta -CTX, TRACP-5b, BMD and other indicators were significantly higher than before treatment, with statistical significance (P0.05). Control group of patients with no significant changes in indicators (P0.05). The total effective rate of control group was 73.33%, the total effective rate of observation group was 93.33%, the difference was statistically significant