尿α1-MG和RBP联合检测在高血压病肾功能损害早期诊断中的价值探讨.docVIP

精品论文 参考文献 尿α1-MG和RBP联合检测在高血压病肾功能损害早期诊断中的价值探讨 （皋兰县人民医院检验科 甘肃兰州 730200） 　　【摘要】目的：探讨联合检测尿alpha;1-微球蛋白（alpha;1-MG）和尿视黄醇结合蛋白（RBP）在高血压病（HD）肾功能损害早期诊断中的价值。方法：选取62例2013年1月～2015年12月间我院收治住院的HD肾功能损害早期患者（疾病组）以及60例同期健康体检者（对照组）作为研究对象，回顾性分析两组在贝克曼库尔特680（AU680）全自动生化分析仪上检测alpha;1-MG、尿RBP、尿微量白蛋白(mALB)、血清肌酐(SCr)和血清尿素(SUrea)的结果。结果：疾病组检测尿alpha;1-MG和尿RBP结果显著高于对照组，比较差异有高度统计学意义（P＜0.01）；检测mALB、SCr和SUrea结果高于对照组，比较差异无统计学意义（P＞0.05）。尿alpha;1-MG和尿RBP分别与mALB、SCr和SUrea呈显著正相关（P＜0.05）。尿alpha;1-MG和尿RBP联合检测阳性检出率为85.48%明显高于单项指标阳性检出率（53.23%，58.06%），比较差异有统计学意义（P＜0.05）。结论：尿alpha;1-MG和尿RBP与肾功能损害密切相关，是肾损害早期诊断中的敏感指标。联合检测可有效提高HD患者早期肾功能损害的检出率,对HD肾损害的早期诊断、预防HD性肾病的发生、发展具有重要的临床价值。 　　【关键词】高血压病；尿alpha;1-微球蛋白；尿视黄醇结合蛋白；早期诊断 　　【中图分类号】R446 【文献标识码】A 【文章编号】1007-8231（2016）17-0126-03 　　 Discussion value of urinary alpha1-MG and RBP combined testing in early diagnosis of renal function damage in patients with hypertension 　　 Wang Jiangrong. The clinical laboratory, Gaolan County Peoples Hospitall, Lanzhou Gansu 730200 China. 　　【Abstract】Objective Discussion on the combined testing of urine microglobulin, alpha1 (alpha;1-MG) and urinary retinol binding protein (RBP) in early diagnosis of renal damage of hypertensive disease (hd) value. Methods Methods 62 cases of early stage of renal function impairment (disease group) and 60 cases of healthy physical examination (control group) were selected from December 2015 to January 2013 in our hospital, and cases were selected as the research objects, Retrospective analysis of the two groups in the Beckman Kurt 680 (AU680) automatic biochemical analyzer to testing urinary alpha;1-MG, urinary RBP, urinary micro albumin (mALB), serum creatinine (SCr) and serum urea (SUrea) results. Results The results of urinary alpha;1-MG and urinary RBP in the disease group were significantly higher than those in the control group, the difference was statistically significant (plt;0.01), testing of mALB, SCr and SUrea results were higher than the control gro