甲氨蝶呤联合米非司酮治疗异位妊娠的效果及安全性分析.docVIP

甲氨蝶呤联合米非司酮治疗异位妊娠的效果及安全性分析 马延平 薛玲娜 西安市临潼区妇幼保健院 韩城市人民医院 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 探讨甲氨蝶呤联合米非司酮治疗异位妊娠的临床效果及安全性。方法 将我院收治的72例异位妊娠患者根据治疗方式不同分为对照组和观察组, 各36例。对照组给予甲氨蝶呤治疗, 观察组在对照组的基础上联合米非司酮治疗。比较两组临床疗效及治疗前、后血清β-HCG水平、包块直径和不良反应发生情况。结果 观察组治疗总有效率为94.4%, 明显高于对照组的72.2% (P0.05) ;治疗后, 两组血清β-HCG水平、包块直径明显优于治疗前, 且观察组明显优于对照组 (P0.05) 。结论 甲氨蝶呤联合米非司酮治疗异位妊娠的临床疗效显著, 且不良反应少, 是一种安全有效的治疗方式, 具有较高应用价值。 关键词： 异位妊娠; 甲氨蝶呤; 米非司酮; 作者简介：马延平 (1970-) , 女, 汉族, 陕西西安人, 副主任医师, 学士。研究方向:妇产科。 作者简介：薛玲娜, E-mail163.com. Therapeutic effect and safety of methotrexate combined with mifepristone in the treatment of ectopic pregnancy MA Yan-ping XUE Ling-na Maternal and Child Health Care Hospital of Lintong District of Xian; Peoples Hospital of Hancheng; Abstract： Objective To investigate the efficacy and safety of methotrexate combined with mifepristone in the treatment of ectopic pregnancy. Methods A total of 72 cases of ectopic pregnancy patients treated in our hospital were divided into control group and observation group according to different treatment methods, with 36 cases in each group. The control group was treated with methotrexate, the observation group was treated with mifepristone on the basis of the control group.The clinical curative effect, the levels of serum β-HCG, mass diameter before and after treatment and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the observation group was 94.4%, which was significantly higher than 72.2% of the control group (P0.05) . After treatment, the levels of serum β-HCG and mass diameter of the two groups were better than those before treatment, and those of the observation group were significantly better than the control group, the differences were statisically significant (P0.05) . Conclusion Methotrexate combined with mifepristone in the treatment of ectopic pregnancy has significant clinical efficacy, and less adverse reacti