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8 前列腺癌-2012-5-23PPT
上帝恩赐的解剖结构 经会阴治疗前列腺癌模式 Modern RT relealize ------ 图像引导技术 剂量提升技术 微创 器官保留 开创肿瘤治疗新时代 High Dose Rate Brachytherapy:Very Well Suited for Prostate Cancer Surgery is no more or less effective than radiation therapy, and elderly or medically frail patients may not be optimal candidates Surgery is associated with significant risks of urinary incontinence and erectile dysfunction Damage to the sphincter muscle or nerves can lead to temporary or permanent urinary incontinence (involuntary urine leaking) Sexual function may be also disturbed due to injury of the neurovascular tissue that runs along side the prostate Nerve-sparing operations reduce the incidence erectile dysfunction, but they should be performed only when there is a high probability that this approach will not compromise complete tumor removal 西雅图放射性粒子治疗经验 前列腺癌粒子植入的奠基人 放射性粒子治疗前列腺癌 美国近距离治疗学会推荐 单纯粒子治疗 T1~T2期 Gleason 2~6级 PSA<10ng/ml 外放疗+粒子治疗 T2b、T2c Gleason 8~10级 PSA20ng/m 单纯放射性粒子治疗结果 粒子治疗+外照射治疗结果 Radical prostatectomy,EBRT72Gy,EBRT72Gy,Seed implantation or combined seed/EBRT for T1-2 prostate cancer Treatment 5-year bRFS 7-year bRFS RP 81% 76% EBRT72Gy 51% 48% EBRT72Gy 81% 81% PI 83 75% COMB 77% 77% Int J Radiat Oncol Biol Phys,2004;58:25-33 Biochemical Relapse-free Survival in Low-Risk Patient Ciezki JP, et al: Oncology 23, 2009 National Tokyo Medical Center National Tokyo Medical Center Biochemical Relapse-free Survival in Intermediate-Risk Patient Ciezki JP, et al: Oncology 23, 2009 BT+EBRT (n=118) RRP (n=82) P0.001 5yrs 46.7% 5yrs 86.1% Seed implant (EBRT combo、no adjuvant hormone) vs RRP Biochemical Relapse Free Survival Rate --For High Risk Cases at NTMC
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