曲美他嗪联合治疗美托洛尔冠心病心力衰竭的临床研究.docVIP

精品论文 参考文献 曲美他嗪联合治疗美托洛尔冠心病心力衰竭的临床研究 陈霞 　　（成都市第五人民医院心内科 四川 成都 611130） 　　【摘要】 目的：观察曲美他嗪联合美托洛尔对于冠心病心力衰竭的临床疗效。方法：选择2014年1月至2014年12月至我院进行冠心病心力衰竭治疗的患者共计78例，随机分为观察组与对照组各39例。对照组：患者入院后行常规治疗，于此基础上给予琥珀酸美托洛尔缓释片初始剂量6.25mg/d。观察组在对照组治疗方案基础上增加盐酸曲美他嗪片20mg/d，餐前服用。观3个月后观察两组患者的临床疗效以及治疗前后患者各项等指标变化情况。结果：经过3个月治疗，观察组16例显效，显效率为41.63%，总有效率为97.44%；对照组显效10例，显效率为25.64%，总有效率为87.18%。观察组的显效率以及总有效率明显高于对照组，且具有统计学差异（Plt;0.05）。治疗前两组患者SBP、DBP、HR、LVEDD、LVESD、LVEF各项指标无组间差异性（Pgt;0.05），经过3个月治疗后，患者各项指标与治疗前相比均有所改善，而且观察组改善的更为明显，与对照组相比较具有统计学差异（Plt;0.05）。结论：曲美他嗪联合美托洛尔对于冠心病心力衰竭具有很好的临床疗效。 　　【关键词】 曲美他嗪；美托洛尔；冠心病；心力衰竭 　　【中图分类号】R97 【文献标识码】A 【文章编号】2095-1752（2016）05-0187-02 　　The clinical research of trimetazidine combined with metoprolol on the treatment of coronary heart disease (CHD) and heart failure 　　Chen Xia ,Department of Cardiology ,The Fifth Peoples Hospital of Chengdu Chengdu, 611130 China 　　【Abstract】Objective To observe the clinical effects of trimetazidine combined with metoprolol on the treatment of coronary heart disease (CHD) and heart failure. Methods 78 cases with coronary heart disease (CHD) and heart failure, which admitted in our hospital during January 2014~ December 2014, were selected as the research object and divided into the observation group and the control group randomly, each group of 39 cases. The control group was given the metoprolol succinate sustained-release tablet initial dose of 6.25 mg/d on the basic of conventional treatment, and the observation group was given the trimetazidine hydrochloride 20 mg/d on the basic of control group before meals. After 3 months, clinical curative effect and various indicators changes of the two groups were observed before and after treatment. Results After 3 months of treatment, the observation group was 16 cases excellent; significant efficiency was 41.63%; total effective rate was 97.44%. The control group was 10 cases were excellent; significant efficiency was 25.64%; total effective rate was 87.18%