生物芯片技术在肺癌研究中的应用价值.PDFVIP

Chin J Lung Cancer, May 2011, Vol.14, No.5 441 中国肺癌杂志2 0 1 1 年5 月第1 4卷第5 期 · · DOI: 10.3779/j.issn.1009-3419.2011.05.11 ·综述· 生物芯片技术在肺癌研究中的应用价值 朱珉 于军 周文利 付向宁 【摘要 】肺癌的发生发展是多基因共同参与、多途径相互影响的复杂生物学进程，与多种癌基因、抑癌基 因、DNA修复基因等变异或表达异常有关。如何从海量数据中寻找肺癌的发病因素和癌变多阶段演进的分子机 制，是目前科研和临床工作者必须面对的问题。生物芯片技术的诞生为人们提供了一种高通量、高效率的肿瘤学 研究手段。本文将讨论生物芯片技术在肺癌中的最新研究进展。 【关键词 】肺肿瘤；生物芯片；诊断；预后 R734.2 【中图分类号 】 Application of Bio-chip in Lung Cancer Research 1 2,3 2 1 Min ZHU , Jun YU , Wenli ZHOU , Xiangning FU 1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 2Department of Electronic Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; 3National Engineering Research Center for Beijing Biochip Technology, Beijing 100084, China Corresponding author: Xiangning FU, E-mail: fuxn2006@ Abstract Lung cancer is a complicated disease involving many genes and important biologic processes. Genetic 【 】 variation or aberrant expression of some oncogenes, tumor suppressor genes and DNA repair genes might be related to its inci- dence and development. How to find out the pathogenic factors of lung cancer and its molecular mechanism of multistage car- cinogenesis from massive data is a key question that researchers and clinicians must answer. The bio-chip technology provid