酸中毒后室性心律失常仿真研究-生物化学与生物物理进展.pdfVIP

See discussions, stats, and author profiles for this publication at: /publication/303178777 Simulation Study of Ventricular Arrhythmia in Post Acidosis Article in Progress in Bioche istry and Biophysics · July 2016 DOI: 10.16476/j.pibb.2016.0070 CITATIONS READS 2 60 5 authors, including: Jieyun Bai Kuanquan Wang University of Auckland Harbin Institute of Technology 76 PUBLICATIONS 14 CITATIONS 3 3 PUBLICATIONS 4,056 CITATIONS SEE PROFILE SEE PROFILE Yongfeng Yuan Harbin Institute of Technology 63 PUBLICATIONS 46 CITATIONS SEE PROFILE Some of the authors of this publication are also working on these related projects: Pre ature Ventricular Co plexes View project Personalized ventricular odeling View project All content following this page was uploaded by Jieyun Bai on 12 July 2016. The user has requested enhance ent of the downloaded file. 生物化学与生物物理进展 Progress in Biochemistry and Biop hys ics 2016, 43(7): 716~724 酸中毒后室性心律失常仿真研究* ** ** *** 刘换岭 白杰云 王宽全 李钦策 袁永峰 (哈尔滨工业大学计算机科学与技术学院，哈尔滨150001) 摘要 本文旨在分析酸中毒对心脏电生理活动的影响，探讨其诱发室性心律失常的机制 首先建立了具有pH 和钙/ 钙调素 依赖蛋白激酶 (calcium/calmodulin dependent protein kinase ，CaMK ) 调控作用的人体心室酸中毒计算模型，然后模拟了 酸中毒过程中细胞和组织电活动的变化，并定量分析了心电图的改变情况 实验结果表明：在酸中毒期间，细胞动作电位时 程的缩短和复极离散度的降低导致心电图QT 间期缩短、T 波幅值和宽度减小 同时，细胞静息电位的抬高和最大去极化速 率的降低也促进了组织电兴奋的缓慢传导和传导阻滞 另外，酸中毒后的初 ，肌浆网钙超载促进钙释放增多，导致细胞产 生延迟后除极(delayed afterd