铜性微弹簧圈栓塞血管的实验研究.docVIP

铜性微弹簧圈的研制及性质评价 姜华 濮进敏 童玉云 李琳 赵洁 李迎春 王家平 昆明医学院第二附属医院放射科，云南 昆明 650101 【摘要】目的： 研究铜性微弹簧圈的制备方法、理化性质和栓塞性能。材料和方法：COOK公司生产的金属导丝外层弹簧圈经热处理制成二级铂金弹簧圈,经过在其表面镀铜,制成二级镀铜弹簧圈。测量二级镀铜弹簧圈表面铜层的厚度、镀铜层的稳定情况、经导管释放及释放后的情况、在生理盐水中铜离子的释放情况及细菌培养情况。观察二级镀铜弹簧圈促血栓形成的作用及时间并与其它栓塞剂做比较。结果：经热处理工艺及镀铜工艺制成的二级镀铜弹簧圈镀铜层稳定,柔韧性好,能从4~7F导管用导丝推送释放并均能回复原状;体外实验表明镀铜弹簧圈有较强的促凝血作用性JIANG Hua，PU Jin-min, TONG Yu-yun，, ZHAO Jie，LI Ying-chun，WANG Jia-ping. Department of Radiology，Second Affiliated Hospital of Kunming Medical University，Kunming 650001，China【Abstract】The secong level platinum micro-coil is made froms from 0.28mm diameter platinum guide wire manufactured by Cook Company which has had the internal mandril removed.We make seeond-level copper coated micro-coil through plating copper on the surface of second level platinum micro-coil.To investigate the flexibility and fixedness of copper coated.In vitro tests,the second-level copper coated coil diameter varying from 3mm to 7mm had been delivered through different catheter pushed by guide wire or sodium chloride injection.Th second-level copper coated micro-coil and platinum micro-coil were preared at random into two containers with antieoagulated artery blood and respeetively observed their coagulative ability and time.Results：We sueeessfully find a method to make second-level copper coated coil,The second-level copper coated coils which are made by ourselves diameter varying from 3mm to 6mm are released from 4F to 7F catheter easily pushed by guide wire.In vitro tests,seeond-level copper coated coil has stronger coagulative ability.Conclusion： Second level copper plated coil have good physical property, rememorability, flexibility and controllability. TheSecond level copper plated coil is supposed to be useful for emoblization therapy. 【Key words】 copper；coil；physical property；embolization 目前应用金属微弹簧圈栓塞进行介入栓塞是一项安全、有效的临床技术，临床应用越来越广泛，但目前应用的栓塞材料—弹簧圈—均为美国或者欧洲产品，价格昂贵，许多患者难以承受，限制了此项技术在临床的推广应用，因此研制国产微弹簧圈十分必要。我们自制一二级的纯铜和镀铜的铜性微弹簧