肿瘤干细胞 分子诊断与靶向治疗.pptVIP

Cancer Stem Cells, Molecular Diagnosis and Targeted Therapy Frequently Asked Questions (FAQ) What are cancer stem cells? Why is research on cancer stem cells important? In what tumor types have cancer stem cells been identified? How are cancer stem cells identified? What happens after stem cells are identified? Are clinical treatments available now to target cancer stem cells? 1. What are cancer stem cells(CSC)? a selectively endowed tumori-genic capacity to recreate the full repertoire of cancer cells of the parental tumor the expression of a distinctive repertoire of surface biomarkers 2. Why is research on cancer stem cells important? weed weed root cancer cancer cancer cancer ---No prairie fire can destroy the grass, it shoots up again with the spring breeze blows. cancer stem cells 3. In what tumor types have cancer stem cells been identified? Leukemia Stem Cells Breast Cancer Stem Cells Head and Neck Cancer Stem Cells Adrenal Cancer Stem Cells Pancreatic Cancer Stem Cells Lung, melanoma, myeloma, prostate and thyroid cancers... 4. How are cancer stem cells identified? Cancer Stem Cell Research Program Goal 1. To investigate potential pathways critical for self renewal, spread and survival of normal and cancer stem cells. Goal 2. To develop new therapies directed against cancer stem cells. 6. Are clinical treatments available now to target cancer stem cells? early stages Initial results are positive additional trials in a larger number of patients will be necessary 6.2 Figure 1 Oxaliplatin-incorporating micelles are effective for the eradication of cancer stem cells (CSCs). Abbreviations: CSO, chitosan oligosaccharide SA, stearic acid Development of nanomedicine for CSCs——Drug-delivery systems for CSCs