Diagnosis and Management of Paget’s Disease of Bon.ppt

Diagnosis and Management of Paget’s Disease of Bone History of Paget’s Disease Sir James Paget named disease osteitis deformans in 1876, suspecting basic inflammatory process1,2 Today predominantly referred to as Paget’s disease of bone1 Epidemiology: Prevalence of Paget’s Disease in the US Genetic Abnormalities in Familial Paget’s Disease Related Disorders Classical Paget’s disease Autosomal dominant Mutations of sequestosome 1/p62 gene (5q 35-qter) Linkage to 5q 31, 18q 21-22, 18q 23, 2q 36, 10p 13 Paget’s disease ,hereditary inclusion body myopathy and dementia Autosomal dominant Mutat