替吉奥联合奥沙利铂治疗晚期胃癌临床观察.docVIP

替吉奥联合奥沙利铂治疗晚期胃癌临床观察 姜林1、2 ， 孔庆志3 ， 胡贤主2 【摘要】?? 目的：观察替吉奥联合奥沙利铂治疗晚期胃癌的近期疗效及毒副反应。 方法?? 70 例晚期胃癌患者, 随机分成对照组与治疗组, 每组各35 例, 治疗组为替吉奥联合奥沙利铂方案，予替吉奥40mg/m2 每天2 次(早晚餐后口服)d1-14, 奥沙利铂100 mg / m2 静滴 d1。对照组为5-氟尿嘧啶、亚叶酸钙联合奥沙利铂方案, 5-氟尿嘧啶500 mg/ m2 静滴 d1-5,亚叶酸钙200mg/m2 静滴d1-5 奥沙利铂100mg / m2 静滴 d1。每28 天为1 个周期. 完成2 个周期以上做疗效评估。 结果?? 治疗组中完全缓解( CR) 1 例, 部分缓解( PR) 14 例, 稳定16 例, 进展4 例。治疗总有效率( CR+ PR) 为42.9%。对照组35例患者中有2例失访，实际统计分析33例。CR 1例, PR8 例, SD 17 例, PD 7 例, 有效率达27.3 %。两组有效率比较差异有统计学意义（P＜0.05) 两组不良反应主要为血液学毒性、消化道反应及外周神经毒性, 但多为Ⅰ度-Ⅱ度毒性反应, 经对症处理绝大多数可以耐受。两组不良反应比较显示：治疗组恶心呕吐反应明显低于治疗组，两组差异有统计学意义（P＜0.05)。而其他不良反应白细胞血液学毒性、腹泻、口腔粘膜炎、手足综合征、外周神经炎、肝功能异常等两组无明显差异（P＞0.05）。 结论?? 替吉奥联合奥沙利铂治疗晚期胃癌的近期疗效较好, 且不良反应轻。 关键词 ??替吉奥；奥沙利铂；晚期胃癌 ?? Clinical Observation of Oxaliplatin Combined With S1 Capsule for Advanced Gastric Cancer JIANG Lin, KONG Qing-zhi, HU Xian-zhu Corresponding auther：KONG Qing-zhi，E-mail：jlallazh@163.com 【Abstract】Objective To explore the early efficacy of Oxalipltin combined with S1 capsule on advanced gastric cancer and observe the toxicity.Methods The observed groups: 35 patients received S1 capsule,40mg/m2,twice a day per oral from day 1 to day 14,and Oxaliplatin 100mg/m2,intravenous drip on day 1.The control group :35 patients received Oxaliplatin 100mg/m2 d1 iV ,5-fluorouracil(5-FU) 500 mg/ m2 d1-5 IV,calcium folinate(CF) 200mg/m2 d1-5 IV.The chemotherapy was repeated every 28 days.All patients received 2 cycles at least efficacy and toxicities were evaluated. Results: In the observed groups the were 1 complete remission(CR),14 partial remission (PR),16 stable disease (SD),and 4 progression disease (PD). The overall response rate was 42.9% in the observed group and 27.3 in the control group . The overall response rate were significantly difference between two groups.(P＜0.05).Main toxicities included leucopenia nausea,vomiting and neurosensory can be accepted by most of the patient.The two groups had similar incidence rate of leucopenia nausea and neurosensory,but the incidence