酮替芬联合孟鲁司特钠对毛细支气管炎后喘息的疗效观察.docVIP

精品论文 参考文献 酮替芬联合孟鲁司特钠对毛细支气管炎后喘息的疗效观察 李江鸿 　　（四川省绵阳市涪城区妇幼保健院 四川 绵阳 621000） 　　【摘要】 目的：探讨酮替芬联合孟鲁司特钠对毛细支气管炎后喘息的临床疗效。方法：对78例毛细支气管炎治愈后近期又有喘息发作的患儿，随机分为两组，对照组急性发作时给予吸入beta;2受体激动剂及糖皮质激素等综合治疗，同时口服孟鲁司特钠，咳喘缓解后继续口服孟鲁司特钠，疗程3个月。观察组在对照组基础上加用1周酮替芬治疗。观察治疗1周内临床症状的改善情况、半年内喘息的发作情况。结果：观察组咳喘消退时间短于对照组，两组比较差异有统计学意义（P＜0.05）。两组半年内喘息发生率相比差异无统计学意义（P＞0.05）。结论：酮替芬联合孟鲁司特钠能明显改善小儿毛细支气管炎后喘息症状，缩短病程。 　　【关键词】 酮替芬；孟鲁司特钠；毛细支气管炎；喘息 　　【中图分类号】R453 【文献标识码】A 【文章编号】2095-1752（2015）13-0149-02 　　Ketotifen Combined with Montelukast Sodium on the Curative Effect Observation after Bronchiolitis Wheezing 　　 Lijianghong Maternal and Child Health Care Hospital of Mianyang District of Fucheng City, Sichuan, Mianyang 621000,China 　　【Abstract】 Objective To investigate the clinical efficacy of ketotifen combined with montelukast in wheezing after bronchiolitis .Methods In 78 cases of bronchiolitis were cured after recent and wheezing in children, were randomly divided into two groups, control group, acute attack given inhaled beta 2 agonists and corticosteroids therapy, and oral montelukast sodium, cough and asthma remission after continuous oral administration of montelukast sodium, period of treatment 3 month. The observation group in the control group based on the use of 1 weeks of ketotifen treatment. The episodes to observe the improvement within 1 weeks of treatment, clinical symptoms within six months of breathing. Results The observation group cough subsided time was shorter than the control group, there was significant difference between two groups (P lt;0.05). Two groups of six months breathing incidence rate had no significant difference（P＞0.05）.Conclusion Ketotifen combined with montelukast sodium can significantly improve the children with bronchiolitis wheezing after symptoms, shorten the course of disease. 　　【Key words】Ketotifen; Montelukast; Bronchiolitis; Wheezing 　　毛细支气管炎（以下简称毛支炎）是2岁以下婴幼儿较常见的下呼吸道疾病，以毛细支气管的黏液分泌增加、上皮细胞坏死及支气管痉挛为特征。急性期经正规治疗后大多迅速恢复[1]。由于当前环境污染和吸