胃癌的LAUREN分型与个体化治疗.FIT)精选.pdfVIP

癌的Lauren 分型与个体化治疗 郑真 谢聪颖 州医科大学附属第一医院袁浙江 温州325000 冤 摘 要 胃癌在全世界和我国均是最常见的恶性肿瘤之一袁虽然目前临床诊疗技术不断提 高袁但大部分胃癌在确诊时偏晚期袁并且部分患者早期手术根治后仍可能发生复发和转移遥 新药及新的临床研究不断运用于临床袁 但晚期患者总体疗效仍然欠佳袁 个体差异较大遥 Lauren 分型将胃癌分为肠型胃癌尧弥漫型胃癌和混 型胃癌袁不同的病理类型有不同的肿 瘤生物学行为袁其预后差异较大遥因而能否根据胃癌的分型对放化疗方案进行优化袁指导临 床进行个体化治疗袁成为目前亟待解决的问题遥 本文就胃癌不同Lauren 分型对不同化疗药 物及放疗的疗效区别进行综述袁以更好地指导临床个体化的治疗遥 主题词 胃肿瘤曰Lauren 分型曰化学药物治疗曰个体化治疗 中图分类号 R735.2 文献标识码 A 文章编号 167 1- 170X doi 10.11735/j.issn.167 1- 170X.20 15. Review on Lauren Classification and Individual Treatments of Gastric Cancer ZHENG Zhen 袁XIE Cong鄄ying The Firs t Affili ated Hosp ital of Wenz hou Medical College 袁Wenz hou 325000 袁China冤 Abstract 院Gastric cancer is one of the most common malignant tumors in the world 袁including China. Although current clinical diagnosis and treatment has been improved greatly 袁most defi鄄 nite diagnosis of gastric cancer has reached advanced stage 袁and some of the patients may have the possibility of recurrence and metastasis after early operation. New drugs and new clinical studies have been continuously used in clinic 袁however 袁the general efficacy of the patients with advanced stages not so good 袁and the individual differences are quite large. Lauren classification has classified gastric cancer into three kinds 袁the intestinal type gastric cancer 袁the diffuse type gastric cancer and the mixed type gastric cancer. According to different pathological types 袁 there are different tumor biological behaviors and the differences of prognosis are quite large. As a result 袁how to optimize the chemotherapy scheme 袁and