冠状动脉病变程度和自主神经功能失平衡之间的关系尚未完全明确.doc

Altered heart rate variability depend on the characteristics of coronary lesions in stable angina pectoris Introduction HRV, which means alteration of intervals among continuous sinoatrial node beats including R-R interval, is a noninvasive, practical and reproducible test for detecting autonomic nervous system function1,2,3,4. It is believed that reduction of HRV reflects inability or attenuation of autonomic nerve system and alteration of sinoatrial node’s response. Moreover, reduced HRV may be related to worse cardiovascular disease 5. Recently, researchers have frequently used time-domain parameters to assess the prognosis effect of HRV among patients suffering different kinds of cardiovascular disease including myocardial infarction, chronic heart failure, unstable angina and diabetes 6,7,8,9. Other studies have shown that dysfunction of autonomic nerve system may be effective in development of atherosclerosis10, but this theory remains controversial, especially for among patients with stable angina11. Furthermore, it is uncertain that whether flexible to explore correlation between them with HRV or not 12, 13, 14. Currently, most studies assessing HRV among subjects with coronary atherosclerotic heart disease have less significance because of specific selection requirements. The significance of HRV among subjects excluded with stable angina and its prediction value in coronary obstruction has been unknown yet 13. In this article, we hypothesize correlation between damage of coronary artery and dysfunction of autonomic nervous system by HRV among subjects with stable angina. Methods and results Subjects Out of 322 subjects receiving selective CAG, 236 patients, hospitalized due to stable angina pectoris because of a history (198 male patients and 38 female patients with the mean age of 59.8±9.5 years) in Cardiology Department of the affiliated He fei hospital of Anhui Medical University from December 2012 to March 2013 were enrolled in this study. Subjects wer