The HCV Life Cycle 丙肝病毒的病毒周期.docxVIP

The HCV Life CycleKey steps in the life cycle of HCV include entry into the host cell, uncoating of the viral genome, translation of viral proteins, viral genome replication, and the assembly and release of virions. All these events occur outside the nucleus of the host cell.Viral EntryVarious factors attributed to the host cell seem necessary to enable HCV entry. The first factor that was identified as necessary for HCV entry was the tetraspanin, CD81. Although CD81 is expressed on many cell types and cannot explain HCVs liver tropism, HCV entry is strongly reduced in the presence of antibodi