硒与甲状腺疾病PPT.pptVIP

硒与甲状腺疾病 2011-10 硒的作用 1、抗氧化功能 2、保护心血管 3、抗辐射损伤能力 4、解毒及抗癌 5、其他功能（未知） 硒在体内的存在形式 1、低分子量的硒化合物 2、硒蛋白的形式： GSH-Px PHG-Px 3、硒代半胱氨酸 SeC 硒蛋白 第一个发现的硒蛋白： GSH-Px 谷胱甘肽过氧化物酶 硒是GSH-Px的必需成分 补硒可使GSH-Px活性增强 GSH-Px分布广泛，在肾脏中浓度最高 GSH-Px可抑制NF-κB的活化 硒蛋白 第二个发现的硒蛋白： PHG-Px 磷脂过氧化谷胱甘肽过氧化物酶 硒是其的必需成分 活性部位与GSH-Px相同 硒化合物 硒代半胱氨酸 Sec Sec与硒蛋白结合，参与到UGA密码子的解码。 硒的摄入 硒：Se 足量摄入： 人每日摄取硒180-280μg 有明显的防癌作用 过量： 人每日摄取硒≥819μg，敏感的人会出现硒中毒症状 硒与疾病 硒化合物和硒蛋白与很多疾病有关： 大骨节病 克罗恩病（CD ） 甲状腺疾病，包括TAO 已与预防某些癌症、阿尔茨海默病、心血管疾病和寿命密切相关。 硒与甲状腺疾病 1、Selenium status and over-expression of interleukin-15 in celiac disease and autoimmune thyroid diseases. 2010 甲状腺对硒缺乏特别敏感，因为含硒蛋白质（含硒代半胱氨酸）在甲状腺激素的生物合成和活动中起着重要的作用 硒与甲状腺疾病 2、Selenium in Human Health and Disease. 2011 selenium in the environment, dietary intakes, metabolism and status, functions in the body, thyroid hormone metabolism, antioxidant defense systems and oxidative metabolism, and the immune system. 硒与甲状腺疾病 3、Selenium and the Thyroid: A Close-Knit Connection. 2010 Context: The recent recognition that the essential trace element selenium is incorporated as selenocysteine in all three deiodinases has decisively confirmed the clear-cut link between selenium and thyroid function. It has additionally been established that the thyroid contains more selenium than any other tissue and that selenium deficiency aggravates the manifestation of endemic myxedematous cretinism and autoimmune thyroid disease. 硒与甲状腺疾病 3、Selenium and the Thyroid: A Close-Knit Connection. 2010 Evidence Acquisition: Clinical reports as well as a large number of biochemical articles linking selenium to thyroid have been considered. Interventional, prospective, randomized, controlled studies, including large observational studies, supplementing selenium in autoimmune thyroid disease, together with review articles published in Medline and Pubmed have undergone scrutiny. The methodo